格拉司琼预防化疗呕吐的有效性和安全性Meta分析

Meta-analysis of effectiveness and safety of granisetron for preventing chemotherapy-induced nausea

目的：了解格拉司琼预防化疗呕吐的有效性和安全性差异。方法：应用Meta分析对21篇文献中研究格拉司琼与其他止吐药物预防化疗呕吐的有效性和安全性进行同质性检验和合并效应量的估计。结果：（1）同质性检验：有效性，χ^2=28．57，自由度为20；安全性，χ^2=26．19，自由度为16，两者P均〉0．05。（2）合并量效的估计：有效性，OR合并=1．879，OR合并95％的可信区间为1．453—2．431。OR合并的检验：0=23．07，P〈0．01；安全性，oR合并=0．760，OR合并95％的可信区间为0．122—0．605。OR合并的检验：χ^2=5．505，P〈0．05。结论：格拉司琼对预防化疗药物引起的呕吐在疗效上总体优于其他止吐药物，且副作用较低。

AIM： To compare the differences in the effectiveness and safety between granisetron and other drugs for preventing chemotherapy-inducecl nausea, METHODS： The effectiveness and safety between granisetron and other drugs for preventing chemotherapy-induced nausea were analyzed by Met,a-analysis in homogeneity test and combined test, RESULTS： Homogeneity test showed that the cited studies of efficacy and safety were homogeneous with χ^2 = 28.57, χ^2 = 26,19, P 〉0.05, respectively, In combined test, the combined OR = 1.879, OR = 0.760 and its 95 % confidence interval was in 1.453 - 2.431, 0.122 - 0.605, respectively. CONCLUSION： The effectiveness of granisetron in treating chemotherapy-induced nausea is significantly superior to those of the medications used at present and the rate of side effects was low.