土元乳液对胃癌化疗药物增效作用的体外研究

Comparative study of synergistic effect of eupolyphaga on chemotherapeutics of digestive canal cancer

目的:比较土元乳液对胃癌化疗药物的体外增效作用。方法:采用MTT法体外药敏试验分别测定土元乳液与羟基喜树碱(HCPT)、氟尿嘧啶(5-Fu)、奥沙利铂(Oxa)、多西紫杉醇(泰素帝)体外对人胃癌细胞系BGC-823细胞株的药物敏感性,通过Weeb系数比较细胞生存率(fa),分析土元乳液对其体外增效作用,得出土元乳液最佳体外增效药物。结果:土元乳液对HCPT、Oxa的高中低3个剂量组体外药敏试验增效作用较好,增效作用明显高于5-Fu、泰素帝组(P<0.05)。结论:土元乳液对HCPT、Oxa有更高的体外增效作用,从而有益于临床上合理配伍用药,更能有效提高临床上联合化疗对肿瘤的抑制率。

AIM：To compare the synergistic effect of eupolyphaga on chemotherapeutics of digestive canal cancer. METHODS： Drug sensitivity of stomach cancer cell （BGC-823） was determined in vitro by MTT anti-tumor screening assay for eupolyphaga with HCPT, 5-Fu, Oxa, docelaxel, by comparing cell inhibition, the synergistic effect of eupolyphaga was analysed to find the best synergistic drug. RESULTS： The synergistic effects of eupolyghaga were more significant in HCPT and Oxa than those of 5-Fu and docelaxel in vitro （ P 〈 0.05）. CONCLUSION： Eupolyphaga has a higher sensitivity in clinical routine chemotherapeutic regimens for stomach neoplamas cells in vitro.