舒降之降低颈动脉狭窄大鼠P300及血清IL-6,CRP水平的实验研究

Effect of Statins on serum IL-6 and CRP level in carotid artery stenosis rats

目的建立双侧颈总动脉重度狭窄的血管性认知障碍大鼠模型,观察舒降之对其认知功能的改变及对血清中IL6,CRP影响。方法用正常SD大鼠制作重度颈动脉狭窄模型后,分为舒降之治疗和生理盐水对照,2周后各组进行听觉事件相关电位(P300),血清IL6,CRP测定。结果舒降之治疗组大鼠P300潜伏期明显小于对照组(P<0.01)、治疗组血浆IL6,CRP水平低于对照组(P<0.01)。结论舒降之可改善血管性认知障碍大鼠的认知功能,其作用机制可能与其抑制IL6,CRP合成有关。

Objective To establish the rat models of severe carotid artery stenosis that leads to vascular congnitive impairment and to observe the effect of Statins on the cognitive function and the serum level of interleukin- 6 （IL-6） and c-reaction protein （CRP）. Methods Sixteen SD rats were randomly assigned to receive intragastric administration of Statins or physiologic saline after rat models of severe carotid artery stenosis by ligating two common carotid arteries were established. Two weeks the serum level of IL-6 and CRP were measured with later, the cognitive ability was determined by P300 test and ELISA. Results The P300 latency and the serum level of the Statins group was significantly decreased as compared with the control group （both P 〈0. 01 ）. Conclusion Statins can improve the cognitive functive of rat with carotid artery stenosis, perhaps by inhibiting inflammation.