强迫症患者的整夜多导睡眠图监测

Evaluation on the Whole Night Polysomnography in Patients with Obsessive- Compulsive Disorder

目的探讨强迫症(OCD)患者多导睡眠图(PSG)睡眠参数的变化特征。方法应用多导睡眠生理仪,采用眼电图和下颌肌电图及脑电图技术,对27例OCD患者的PSG进行整夜监测,并与33名正常受试者(NC)对照。结果OCD组快速眼运动(REM)睡眠潜伏期为(57.7±21.4)min,较NC组的(87.8±11.7)min明显前移(P<0.01)。OCD组患者的REM活动度、强度、密度以及第1阶段睡眠均较NC组明显增加,分别为(119.8±54.5)Uvs(80.7±9.2)U(P<0.01)、(27.8±13.4)%vs(17.8±2.3)%(P<0.01)、(147.4±69.2)%vs(95.7±8.1)%(P<0.05)、(19.9±11.4)%vs(9.1±1.9)%(P<0.01);而睡眠潜伏期延迟,睡眠效率降低。结论PSG中的REM活动度、强度和密度均增加,可能是强迫症患者的脑电生理学特点。

Objective To assess the changes on the whole night polysomnography （PSG） in patients with obsessive-compulsive disorder（OCD）. Methods The whole night PSGs were recorded from 27 patients with OCD and 33 normal subjects. Results Compared with normal subjects, OCD patients showed significantly shortened rapid eye movement （REM） latency （ [87.8 ± 11.7 ] min vs [ 57.7 ± 21.4 ] min, P 〈 0.01 ）, increased REM activity （ [ 80.7 ± 9.2]Uvs [119.8±54.5]U, P〈0.01）, increased REM intensity（ [17.8 ±2.3]% vs [27.8 ±13.41%, P〈 0.01 ）, increased REM density （ [ 95.7 ±8.1 ] % vs [ 147.4 ±69.2 ] %, P 〈 0.05）, increased stage 1 sleep （ [ 9.1 ± 1.9 ] % vs [ 19.9 ± 11. 4 ] %, P 〈 0.01 ）, delayed sleep latency, and reduced sleep efficiency. Conclusion REM activity, intensity, and density of PSG might be specific to OCD patients.