焦虑症患者睡眠神经生理实验研究

Evaluation on the Whole Night Polysomnography in Patients with Anxiety

目的探讨建立焦虑症(AN)患者的多导睡眠图(PSG)模式。方法应用多导睡眠生理仪,采用眼电图和下颌肌电图及脑电图技术,对24例AN患者和33名正常对照(NC)者进行PSG整夜监测。结果与NC组比较,AN组PSG主要有:REM睡眠潜伏期前移,NC组(87.8±11.7)min,AN组(59.9±19.7)min(P<0.01);醒觉时间增加,NC组(17.7±6.4)min,AN组(36.9±11.9)min(P<0.01);睡眠潜伏期延迟,NC组(19.9±9.8)min,AN组(37.7±16.7)min(P<0.01);睡眠效率下降,NC组(94.6±5.1)%,AN组(90.5±5.7)%(P<0.05)。第1阶段睡眠增高,NC组(9.1±1.9)min,AN组(19.7±10.9)min(P<0.01);第2阶段睡眠降低,NC组(56.2±4.7)%,AN组(47.7±22.3)%(P<0.05)。结论焦虑症组有REM睡眠潜伏期前移、慢波睡眠S2降低等多项睡眠脑电指标的异常,其睡眠障碍的病理机制可能同源于发病机制。

Objective To assess the changes on whole night polysomnography （PSG） in patients with anxiety. Methods The whole night PSGs were recorded from 24 patients with anxiety and 33 normal subjects. Results Compared with normal subjects, patients with anxiety showed significantly shortened REM latency（ [87.8 ± 11.7 ] min vs [59.9 ± 19.7] min, P 〈0.01）, increased waking time （[ 17.7 ±6.4] min vs [36.9 ± 11.9] min, P 〈 0.01）, prolonged sleep latency （ [ 19.9 ± 9.8 ] min vs [ 37.7 ± 16.7 ] min, P 〈 0.01 ）, reduced sleep efficiency （[94.6±5.11% vs [90.5±5.71%, P〈0.05）, increased stagel （[9.1 ±l.9]minvs [19.7±10.9]min, P〈 0.01）, and decreased stage 2 （ [ 56.2 ± 4.7 ] % vs [ 47.7 ± 22.3 ] %, P 〈 0.05）. Conclusion Patients with anxiety exhibit abnormalities in shortened REM latency and decreased slow wave sleep, suggesting that sleep abnormalities might arise from anxiety pathophysiology.