焦虑症的事件相关电位P_(300)实验研究

Experimental Study of Anxiety Disorder on Event-Related Potentials P_(300)

目的观察焦虑症(AD)听觉事件相关电位P300的变化特点。方法对30例AD患者和30名健康成年人(NC组),应用脑诱发电位仪进行P300检测。结果与NC组相比,AD组Pz点P3潜伏期后移,NC组为(326±16)ms,AD组为(339±19)ms(P<0.01);P3波幅降低,NC组为(6.0±1.9)μV,AD组为(4.5±2.2)μV(P<0.05);非靶P2波幅降低,NC组为(3.8±0.9)μV,AD组为(1.7±0.8)μV(P<0.01)。结论AD患者P300变化诸特点值得进一步随访。

Objective To study the characteristics of event-related potentials P3oo in patients with anxiety disorder （AD）. Methods P3oo tests were carried out in 30 patients with AD and 30 healthy adult controls. Results Patients with AD had significantly delayed P3 latency （ [326 ±16] ms vs [339 ± 19] ms, P 〈0.01 ）, decreased P3 （ [ 6.0 ± 1.9 ] μV vs [ 4.5 ± 2.2 ] μV, P 〈 0.05 ） and P2 [ 3.8 ± 0.9 ] μV vs [ 1.7 ± 0.8 ] μV, P 〈 0.01 ） amplitude of P3oo at Pz. Conclusion The characteristics of P3oo of patients with AD deserve further studies.