多巴胺D4受体基因与强迫症的关联

Association between Dopamine Receptor D4 Gene Polymorphism and Obsessive-Compulsive Disorder

目的探讨多巴胺D4受体基因多态性同强迫症(OCD)的关系。方法采用PCRAmFLP技术测定96例OCD患者和83例健康对照者(NC)的基因型,并根据OCD患者首次发病年龄进行亚组划分。结果共检测到DRD4基因48bp可变数目重复序列的5种等位基因和8种基因型,OCD组与NC组间基因型和等位基因频数分布均无显著差异(P>0.05)。早发型OCD患者DRD4基因型和等位基因频数分布与NC组存在显著性差异(P<0.05),而晚发型患者基因型和等位基因频数分布与NC组无显著性差异(P>0.05)。结论在该组患者中DRD4受体基因与早发型OCD存在关联,3/4基因型可能是早发型OCD的风险因子。早发型和晚发型的OCD可能具有不同的发病机制。

Objective To explore the relation between polymorphism of dopamine receptor D4 （ DRD4 ） gene and obsessive-compulsive disorder（OCD）. Methods Ninety-six OCD patients and 83 healthy controls were enrolled in this study. All subjects were genotyped directly via polymerase chain reaction amplification fragment length polymorphism techniques. OCD patients were divided into two subgroups according to the onset ages. Results Five alleles and eight genetypes of 48 bp polymorphism had been detected in the exon 3 of DRD4. There were no significant differences of genotype and allele frequencies of DRD4 between OCD patients and controls （P 〉0.05）. After dividing the patients into early-onset and late-onset frequency between early-onset patients and subgroups, there were significant differences of DRD4 genotype and allele controls （P 〈 0.05） ,while no significant differences existed between lateonset patients and controls （P 〉 0.05）. Conclusion The results suggested that the polymorphism of DRD4 receptor gene may be associated with early-onset OCD. The 3/4 genetype may be the risk factor of early-onset OCD. Early-onset and late-onset OCD may have different etiology.