抑郁障碍患者血小板5-HT浓度随访研究

Follow-up Study on Platelet 5-HT Content in Patients with Depressive Disorder

目的对抑郁障碍(DD)患者进行平均4.5年的随访,测定其血小板5HT浓度。方法采用高效液相色谱法(HPLC)测定22例DD患者治疗前和随访时血小板5-羟色胺(5HT)浓度,通过自身前后对照,分析DD患者前后2次血小板5HT浓度改变与不同预后组之间的关系。结果在随访样本中,随访时测血小板5HT浓度为(301.14±64.20)μg/L,较基线(214.29±45.69)μg/L有所升高,但无显著性差异(P>0.05)。但依据汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)两项联合评估法分组和HAMD、HAMA、社会功能程序缺隐筛选量表(SDSS)三项联合评估法分组,预后良好组血小板5HT升高有显著性差异(P<0.05)。结论DD患者存在5HT系统代谢异常,血小板5HT是DD的一个状态指标,可以尝试用来预测疾病的预后。

Objective To explore the relationship between the change of platelet 5-HT content after an average of 4.5 years natural course and the different prognosis in patients with depressive disorder. Methods The platelet serotonin level of the sample was determined by high performance liquid chromatograpy. The change of platelet 5-HT content was compared before and after the treatment among the different prognosis groups. Results The platelet 5-HT content of the samples during follow-up （ [ 301. 14 ±64.20 ]μg/L） was higher than the baseline （ [ 214.29 ± 45.69 ] μg/L） , but there was no significant difference（ P 〉 0.05）. Using Hamilton depression （HAMD） and Hamilton anxiety （HAMA） rating scales, or using HAMD, HAMA and social disability screening schedule （SDSS） to determine the prognosis groups, the change of platelet 5-HT content had significant difference in the group with good prognosis （P 〈0.05）. Conclusion There is abnormal activity of 5-HT system in depressive disorder. Platelet 5-HT content is the state indicator of depressive disorder and may be used to predict prognosis.