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甲氧氯普胺在分化型甲状腺癌患者随访中的应用 被引量:1

Application of metoclopramide in follow-up of patients with differentiated thyroid carcinoma
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摘要 对分化型甲状腺癌(DTC)患者随访时,需停用左旋甲状腺素(L-T4)4—6周,检测血清甲状腺球蛋白及^131I-全身显像,以利于早期发现DTC病灶复发和转移。本研究将甲氧氯普胺(MCP,胃复安)用于随访的DTC患者,结果显示MCP没有明显升高TSH,其临床应用有待于进一步研究。 During following-up the patients with differentiated thyroid carcinoma (DTC), it is necessary that L-T4 has to be held for 4-6 weeks for determining serum thyroglobulin level and performing ^131I whole body scann, so that recurrence and metastasis of DTC may be discovered early. In this study, the metoclopramide (MCP) was applied in DTC patients during following up and the results showed that serum TSH level was not changed by MCP and the clinical application of MCP should be subjected to further investigation.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2006年第2期114-115,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 甲氧氯普胺 甲状腺肿瘤 促甲状腺素 多巴胺 Metoclopramide Thyroid neoplasms Thyrotropin Dopamine
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参考文献5

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  • 2Morley JE, Neuroendocrine control of thyropin secretion. Endocr Rev, 1981,2:396-436.
  • 3Dyess EM, Segerson TP, Liposits Z, et al. Triiodothyroxine exerts direct cell-specific regulation of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus. Endocrinology, 1988,123 :2291-2297.
  • 4Grebe SK, Delahunt JW, Feek CM, et al. Lack of evidence for pituitary thyrotroph down-regulation after 1 week of oral thyrotropin-releasing hormone and metoclopramide under conditions of constant peripheral thyroid hormone levels. Eur J Endocrinol, 1995,132:331-337.
  • 5Radetti G, Bernasconi S, Bozzola M, et al. Pyridostigmine and metoclopramide do not restore the TSH response to TRH inhibited by Lthyroxine treatment in children with goiter. J Endocrinol Invest, 2000,23:744-747.

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