Graves眼病患者T细胞亚群的研究

Study on T lymphocyte subsets in patients with Graves′ ophthalmopathy

采用流式细胞仪检测早期Graves眼病(GO)组、非突眼Graves病(GD)组和正常对照组的T细胞亚群、IFN-γ^+T细胞和IL-4^+T细胞。结果显示早期GO存在T细胞亚群失衡,以CD_4^+Th1细胞介导的细胞免疫为主。

T cell subsets, the IFN-γ^＋ T lymphocyte （represent Th1-like cytokines） and the IL-4^＋ T lymphocyte （represent Th2-like cytokines ） were assayed by flow cytometry in patients with early Graves＇ ophthalmopathy （GO）, patients with initial Graves＇ disease （GD） without ophthalmopathy and normal subjects. There was an imbalance of T cell subsets during early GO. The Th1-type CD4^＋ T cell-mediated immunity might play a predominant role in the pathogenesis of early GO.