摘要
本研究利用ＢＡＥＰ检测对２７例应用常规剂量氨基甙类抗生素（链霉素、庆大霉素、卡那霉素）的患儿进行门诊随访研究，以了解此类药物的耳毒性及远期影响。２７例中，男１７例，女１０例。用药时平均年龄２岁零４个月（２个月～８岁）。用药前均无听力障碍。随访时平均年龄１２岁（５岁～１９岁），随访时间最长１５年。最短３年。结果发现：２７例患儿中，１例听力稍差，１７例２２只耳ＢＡＥＰ异常，即Ⅰ、Ⅱ波潜伏期延长；Ⅰ－Ⅴ波峰间潜伏期缩短；耳间差＞０．４ｍｓ。随访中有４例患儿，治疗前ＢＡＥＰ正常，治疗后４天复查，ＢＡＥＰ异常３例。说明氨基甙类抗生素耳毒性副作用相当多见，而且出现较早；ＢＡＥＰ异常是其耳毒性的早期表现之一，可作为停药的指征。
A follow-up study was performed by brainstem auditory evoked potentials (BAEPs) on 27 patients with aminobiotics treatment in an ordinary dosage. The results showed that one patient had mild disturbance in the auditory perception .BAEP was abnormal in 22 ears of 17 patients. The abnormality of BAEP included the prolongation of the peak latencies in wave Ⅰ and Ⅱ,the shortening of the interpeak latencies in wave Ⅰ - Ⅴ,the peak latency difference between the two sides was greater than 0.4 ms. Four patients were normal on BAEP before aminobiotics, but four days later, 3 of the 4 patients were found to be abnormal on BAEP,suggesting that the ototoxity of aminobiotics was very common in children, and it occured earlier. The abnormal BAEP,one of the early signs of the ototoxity, might be used as the index to stop aminobiotics.
