高剂量左氧氟沙星治疗呼吸系统感染的安全性与有效性的病例对照分析

Case-control analysis of the efficacy and safety of high dosage levofloxacin in the treatment of respiratory system infections

目的观察大剂量左氧氟沙星静滴治疗呼吸系统感染的安全性与有效性。方法对70例呼吸道细菌感染患者，分为高剂量左氧氟沙星（可乐必妥）500mg／d一次静脉滴注的治疗组和常规剂量300mg／次每天两次静脉滴注的对照组，疗程5～10天后进行治疗前后两组间的比较。结果治疗组和对照组的临床总有效率分别为93．3％和91．6％，经统计学处理差异无显著性；不良反应发生率治疗组和对照组分别为6．6％和6．1％，两组间无统计学意义；但三日症状缓解率差异有统计学意义，且总疗程治疗组较对照组缩短。结论高剂量左氧氟沙星治疗呼吸道感染疗效良好，副作用较小，不良反应较少，是治疗轻中重度呼吸系统感染较理想的药物。

Objective To observe the efficacy and safety of high dosage by vein drop in treatment of respiratory system infection. Methods Seventy patients were enrolled in the trial and they were divided into two groups. The trial group was given levofloxacin 500mg once daily and control group was given levofloxacin 300mg twice daily. The course of treatment was 5 to 10 days in both groups. Results The clinical efficacy rate in the trial and control groups were 93.3% and 91.6% respectively; the difference was not of much statistical significance between the two groups. Adverse reactions observed in 6.6% and 6.1% of patients in the two groups respectively, were of no statistical significance. But after three days, the difference in the rate of alleviating is of statistical significance. The course of treatment of the trial group is shorter than that of the control group. Conclusions High dosage levofloxacin is effective in the treatment of respiratory system infections with little adverse reactions. So it is ideal pharmacy for treatment of midrange and severe respiratory system infections.