伴高血压、糖尿病的脑梗死患者血小板活化水平与意义

The levels and significance of platelet activation in cerebral infarction patients accompany hypertension and diabetes

目的观察伴高血压和/或糖尿病的脑梗死患者血小板活化水平的变化,探讨其在疾病发生中的作用与意义。方法采用流式细胞术测定40例健康对照组和352例急性脑梗死患者血小板活化指标CD62P、CD63的水平,同时对脑梗死患者按伴发疾病不同,分为高血压组、糖尿病组、高血压并糖尿病组,然后进行组间比较。结果脑梗死患者血浆CD62P、CD63水平明显高于对照组(P<0．001);高血压并糖尿病组脑梗死患者血浆CD62P、CD63水平明显高于高血压纽(P<0．01);但与糖尿病组比较无显著差异(P>0．05);糖尿病组CD62P水平明显高于高血压组(P<0．05),而CD63水平比较无统计学差异(P>0．05)。结论急性脑梗死早期活化血小板水平明显增高,伴有糖尿病及高血压并糖尿病的脑梗死患者活化血小板水平增高更加显著。

Objective To observe the levels of platelet activation in cerebral infarction patients accompany hyp rtension and diabetes, and explore its role and significance during the course of disease. Methods To perform the index levels of platelet activation. CD62P, and CD63. by flow eytnmetry in 352 patients with cerebral infarction （CI） and matched with 40 normal controls （NC） .The patients were divided into three gropos.group with hypertension （H）, group with diabetes （D） and group with both of the two diseases （HD）, and then compared with each other, Results The index level of patients with CI was higher than thai in NC （ P 〈 0.001 ） ; the level of HD was higher than that of H （ P 〈 0.01 ）, but no significance （ P 〉 0.05） when compared with D.The CD62pwas increased in the patients with D compared with that of H （ P 〈 0.05）, but the change of CD63was no significance. Conclusion The numerical value of platelet activation enhanced in the patients with acute cerebral infarction; and it should be much higher when accompany diabetes （or with hypertension simultaneously） .