胶质瘤中HIF-1α的表达及其与增殖指标ki67的关系

Hypoxia inducible facter-1 expression and its relation to proliferation index ki67 in gliomas

目的:研究在胶质瘤中H IF-1α和k i67的表达之间的相互关系。方法:免疫组织化学方法检测60例胶质瘤病例中H IF-1α和k i67的表达。结果:在60例胶质瘤病例中,H IF-1α的阳性率为71.7%(43/60),高级别胶质瘤的阳性表达率(89.7%),显著高于低级别的胶质瘤阳性表达率(54.8%)(P<0.05)。K i67的阳性表达率为65%(39/60);在H IF-1α与k i67表达之间存在正相关关系(P<0.05)。结论:H IF-1α与胶质瘤细胞增殖相关。

Objective： This study was designed to investigate the expression of hypoxia inducible factor -1α（HIF-1α） and its relation to ki67 in gliomas. Methods： Immunohistochemical staining was used to examine the expression of HIF-1α and ki67 in 60 cases of glioma. Results： In 60 cases of glioma, the positive rate of HIF-1α expression was 71.7% （43/60）, especially the positive rate of higher histological grade gliomas（89. 7%） was significantly higher than that of lower histological grade gliomas （54.8%） （P 〈（0.05）. The positive rates of ki67 expression was 65% （39/60）; and the relationship between HIF-1α and ki67 was also positive （ P 〈 0. 05 ）. Conclusion. HIF-1α is correlated with the proliferation of glioma cells.