蜂花粉多糖液抑制肿瘤作用的实验研究

Studies on the Inhibiting Effect of Honeybee Pollen Polysaccharide on the Proliferation of Sarcoma 180 Cells in Tumor-bearing Mice

通过对小鼠腋下移植肿瘤S180后给荷瘤小鼠灌胃花粉多糖液,以观察花粉多糖液对肿瘤的抑制作用。将60只荷瘤小鼠随机分为环磷酰胺组(50 mg/kg)、阴性对照组、花粉多糖实验组,实验组连续给小鼠灌胃花粉多糖液10 d。结果表明:800 mg/kg花粉多糖组可明显降低瘤体重量,抑瘤率明显提高,达43.63%,与对照组比较差异显著,并呈剂量-效应关系。同时,吞噬指数与肿瘤对照组比较差异具极显著。结果显示花粉多糖液达到一定浓度时具有抑制肿瘤和提高小鼠腹腔巨噬细胞的吞噬作用。

To investigate the inhibitory effect of the honeybee pollen polysaccharide（HPP） on proliferation of S - 180 cells in tumor - bearing mice, sixty tumor - bearing mice were radomized into cyclophospharmide （CTX） group, negative control and HPP experimental group. The HPP experimental group of tumor - bearing mice were given HPP by gastric filling method for 10 days. The rate of inhibitory effect and index of phagocytosis were oberved. The results were：the HPP experimental group（800 mg/kg · d × 10 d） showed reduced weight of tumor. The rate of inhibitory effect attained 43.63%. It indicates that HPP inhibits tumor growth, and can be used to control tumor.