环境神经毒物(锰)对神经细胞毒作用的分子机制

Mechanisms for Environmental Neuroxicants-induced Neurotoxicity

机体接触过量的环境神经毒物(如锰粉尘)能产生慢性神经毒性(锰中毒)。环境神经毒物引起神经细胞的毒作用机制受到国内外学者广泛关注。锰中毒是一种常见的职业病,其临床表现类似巴金森病的症状。长期研究观察发现, 锰暴露人群锰中毒的发病存在明显的个体差异,因此锰中毒发生的机制还与遗传易感性有关。

Recent review has implicated chronic exposure to environmental agents, such as metal（ e.g manganese, Mn ）and MPP＋ ）, MPTP, as contributors to neurological diseases. Mechanisms for environmental neuroxicants-induced neurotoxicity have been focused by scientists. Chronic manganism causes an extrapyramidal syndrome with features resembing those of Parkinsong＇ s disease. The fact that only a fraction of workers exposed to manganese developed nervous system dysfunction suggests the presence of genetic predisposition in some persons. Thereby, the genetic susceptibility to manganism also involved in mechanisms for manganese-induced neurotoxicity.