奥氮平联合氟西汀治疗精神分裂症阴性症状的对照研究

A controlled trial of olanzapine and fluoxetine in treatment of negative symptoms of schizophrenia

目的探讨奥氮平联合氟西汀治疗精神分裂症阴性症状的疗效及安全性。方法将以阴性症状为主的精神分裂症患者分为奥氮平合用氟西汀组32例和单用奥氮平组30例,两组均以PANSS量表减分情况评定疗效,TESS量表评定药物不良反应,共观察8周。结果(1)奥氮平合用氟西汀组与单用奥氮平组治疗精神分裂症的有效率为90.63%和73.33%(P>0.05),显效率为75.00%和40.00%(P<0.01)。(2)PANSS总分减分及PANSS阴性因子分减分在第2、4、8周末奥氮平合用氟西汀组均优于单用奥氮平组(P<0.05或0.01)。(3)两组药物的不良反应少,奥氮平合用氟西汀组的体重增加明显低于单用奥氮平组(P<0.05)。结论奥氮平联合氟西汀治疗能明显改善精神分裂症的阴性症状,且安全性好。

Objective To compare the efficacy and safety of olanzapine and fluoxetine in treatment of negative symptoms of schizophrenia. Methods 32 patients with negative symptoms were treated with olanzapine and fluoxetine, 30 patients were treated with olanzapine. PANSS and TESS scales were used to evaluate the efficacy and safety for 8 weeks. Results （1）The effect rate in olanzapine and fluoxetine group was 90.63%, whereas that was 73.33% in olanzapine group （P〉0.05）. The apparent effect rate in olanzapine and fluoxetine group was 75%, whereas that was 40% in olanzapine group（P〈0.01）. （2） Olanzapine and fluoxetine group was superiority to olanzapine group in the 2nd, 4th, 8th weeks （P〈0.01） of PANSS total scores＇ subtraction and in the 2nd week （P〈0.05）, the 4th, 8th weeks （P〈0.01） of PANSS negative scores＇ subtraction. （3） Two groups had significantly fewer side effects. Conclusion Olanzapine and fluoxetine demonstrated to have satisfactory effect and safety in treating negative symptoms of schizophrenia.