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海马锥体神经元树突中电压依赖性钾通道研究进展

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摘要 海马锥体神经元树突上分布着多种电压依赖性钾离子通道,但这些通道在胞体和树突不同部位的分布密度以及在突触电活动中的功能意义各不相同。倒传递动作电位(b-AP)和兴奋性突触后电位(EPSP)是树突中常见的功能电信号。本文简要介绍了近年来海马锥体神经元树突上这些钾离子通道及其电活动的生理和病理学研究成果。
出处 《生理科学进展》 CAS CSCD 北大核心 2006年第2期138-140,共3页 Progress in Physiological Sciences
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参考文献10

  • 1Hoffman D,Magee JC,Colbert CM,et al.K^+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons.Nature,1997,387:869-875.
  • 2Rhodes KJ,Carroll KI,Sung MA,et al.KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.J Neurosci,2004,24:7903-7915.
  • 3Holmqvist MH,Cao J,Hernandez-Pineda R,et al.Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.Proc Natl Acad Sci USA,2002,99:1035-1040.
  • 4Shibata R,Misonou H,Campomanes CR,et al.A fundamental role for KChIPs in determining the molecular properties and trafficking of Ky4.2 potassium channels.J Biol Chem,2003,278:36445-36454.
  • 5Ngo-Anh TJ,Bloodgood BL,Lin M,et al.SK channels and NMDA receptors form a Ca^2+-mediated feedback loop in dendritic spines.Nat Neurosci,2005,8:642-649.
  • 6Gu N,Vervaeke K,Hu H,et al.Kv7/KCNQ/M and HCN/h,but not KCa2/SK channels,contribute to the somatic medium after-hyperpolarization (mAHP)and excitability control in CA1 hippocampal pyramidal cells.J Physiol,2005,566:689-715.
  • 7Cai X,Liang CW,Muralidharan S,et al.Unique roles of SK and Kv4.2 potassium channels in dendritic integration.Neuron,2004,44:351-364.
  • 8Mockett B,Coussens C,Abraham WC.NMDA receptor-mediated metaplasticity during the induction of long-term depression by low-frequency stimulation.Eur J Neurosci,2002,15:1819-1826.
  • 9Bernard C,Anderson A,Becker A,et al.Acquired Dendritic Channelopathy in Temporal Lobe Epilepsy.Science,2004,305:532-535.
  • 10Misonou H,Mohapatra DP,Park EW,et al.Regulation of ion channel localization and phosphorylation by neuronal activity.Nature Neurosci,2004,7:711-718.

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