3Conklyn M,Andresen C,Changelian P,et al.The JAK3 inhibitor CP-690550 selectively reduces NK and CD8^+ cell numbers in cynomolgus monkey blood following chronic oral dosing.Leukoc Biol,2004,76:1248-1255.
4Kudlacz E,Perry B,Sawyer P,et al.The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models.Am J Transplant,2004,4:51-57.
5Borie DC,Changelian PS,Borie DC,et al.Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates.Transplantation,2005,79:791-801.
6Cetkovic-Cvrlje M,Uckun FM.Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft-versus-host disease (GVHD) in a murine allogeneic bone marrow transplantation model.Br J Haematol,2004,126:821-827.
7Barton BE,Karras JG,Murphy TF,et al.Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer:Direct STAT3 inhibition induces apoptosis in prostate cancer lines.Mol Cancer Ther,2004,3:11-20.
8Muthian G,Bright JJ.Quercetin.a flavonoid phytoestrogen,ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte.Clin Immunol,2004,24:542-552.
9Kumar S,Raje N,Hideshima T,et al.Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs.Leukemia,2005,19:1253-1261.
10Jacobsohn DA,Vogelsang GB.Anti-cytokine therapy for the treatment of graft-versus-host disease.Curr Pharm Des,2004,10:1195-1205.
