急性心肌梗塞静脉溶栓100例临床分析和体会

Experience of Intravenous Thrombolytic Therapy for Acute Myocardial Infarction in 100 Cases

本文对我院心内科在１９９１－１９９５年间施行静脉溶栓治疗的１００例急性心肌梗塞病例的临床资料进行了分析总结，结果：血管通畅率６１％，其中尿激酶５７％，链激酶７１％；总死亡率６％，其中血管再通组和未通组分别为１．６％或１２．８％（Ｐ＜０．００１）；再通组的心衰和严重室性心律失常的发生率均明显低于未通组，且左室射血分数明显高于未通组；溶栓在梗塞发作６小时内开始者其通畅率远远大于６－１２小时者，我们认为在严格排除禁忌证，确定适应证后，溶栓治疗应尽早开始；同时严密心电血压监测，以增加成功率和安全性。

To evaluate the effect of intravenous thrombolytsic therapy in acute myocardial infarction(AMI),100 cases of AMI admitted to Beijing Anzhen Hospital during 1991 to 1995 were studied.The results showed that the average patency rate of thrombolytic threapy was 61% for the whole study group,including 57% with Urokinase and71%with Streptokinase.The total mortality was 6%,of which 1.6% in the patent group and 12.8%in the non-patent group(p<0.001),respectively.Moreover,the morbidities of heart failure and severe ventricular arrhythmia were lower,and LVEF was higher in the patent group than in the non-patent group.the patency rate was higher in patients received thrombolytic therapy within 6 hours than 6～12 hours after onset of AMI.