氧化苦参碱预防胃肠癌辅助化疗中的毒副作用

Clinical analysis of Oxymatrine in the prevention of side effects and toxicity in gastrointestinal malignancy chemotherapy

目的 探讨氧化苦参碱在预防胃肠癌化疗过程中血液以及肝肾毒副作用中的临床价值。方法 选择2002年1月至2005年1月间的60例胃肠癌手术后病人，随机分为两组，每组30例，治疗组在化疗的同时应用氧化苦参碱600mg／d，d1-12，不加用氧化苦参碱的为对照组。化疗结束后，查血常规、肝肾功能，对两组之间的毒副作用的差异进行评估。结果 治疗组的28例历经148次化疗，骨髓造血、肝肾功能无明显变化，而对照组29例历经158次化疗，骨髓造血和肝肾功能有明显变化。结论 氧化苦参碱可有效地预防胃肠癌术后化疗过程中出现的毒副作用，提高化疗的安全性。

Objective To evaluate the efficacy of Oxymatrine in the prevention of side effects and toxicity in gastrointestinal malignancy chemotherapy. Methods 60 postoperation patients with gastrointestinal malignancy （from Jan 2002 to Jan 2005） were randomized into 2 groups： 30 patient in each group. In the treatment group, oxymatrine was applied into the prevention of side effects and toxicity in chemotherapy （600mg/d, 1-12d）, in control group, the patients received only chemotherapy. Side effects and toxicity were evaluated by checking blood routine test, liver and renal function after chemotherapy. Results 148 cycles of chemotherapy （28 patients） were completed in the treatment group, in which no significant change of blood routine test and liver and renal function was documented. Significant changes were documented in 158 cycles of chemotherapy （29 patients） completed in the control group. Conclusions Oxymatrine could prevent side effects and toxicity in gastrointestinal malignancy chemotherapy and promote the efficacy and safety.