宫颈非典型性鳞状上皮不成熟化生

Atypical immature metaplasia of squamous epithelial in the cervix

宫颈移行区是鳞状上皮变化广泛的区域，目前宫颈疾病中最不能明确定义的病变是非典型性鳞状上皮不成熟化生（atypical immature metaplasia，AIM），这是一个缺少特征的宫颈病变，国内外公开的研究报道很少，其生物学和临床意义尚不明确，由于仅从形态学上观察常常把AIM误诊为宫颈上皮内瘤变，造成不必要的过治疗和医疗卫生资源的浪费，又缺乏一个可以被接受的、便于常规临床病理工作参考的诊断标准，根据复习文献和我们的观察，我们从细胞分化、粘液染色、Ki、67标记指数、组织学特征等方面对AIM的诊断标准提出一个综合性的诊断参考标准。

The cervical transformation zone plays host to a wide spectrum of squamous epithelial alterations, the most undetermined significant lesion in the cervix is atypical immature metaplasia （AIM）. It is a poorly characterized cervical lesions with uncertain biological and clinical significance, the related reports are rare. Only by morphological observation, AIM often be misdiagnosised as cervical intraepithelial neoplasia, leading to unnecessary overtreatment and waste of medical resources. On the other hand, there isn＇t a classic diagnosis criterion which is acceptable and suit for normal clinical pathological work. According to literatures and practice, we have expound a synthetic diagnosis criterion from cell differentiation, PAS-stainning, Ki-67 index and histological characters.