组蛋白酶D与宫颈癌

Cathepsin D and cervical cancer

在宫颈癌中，影响治疗和预后的临床分期是最重要的因素．但仅靠临床分期是不够的，于是需要发现一种更好的预后指标，异常的组蛋白酶D升高被发现在癌细胞中，这种过度表达被认为是通过对胞外基质的消化而增加肿瘤的转移潜力，在局部进展期宫颈癌中，高组蛋白酶D水平相关于短期的无复发生成。

For cervical cancer, clinical staging has been the most important single parameter influencing choice of treatment and indicating outcome .However, it is not enough to depend on the clinical staging. There is a need to find better prognostic indicators for cervical cancer. Abnormally high levels of Cathepsin D are found in cancer cells, and this overexpression is believed to increase the metastatic potential of the tumor by digestion of the extracellular matrix, Cathepsin D positive turners are associated with a shorter disease free survival in patients with locally advanced cervical cancer.