溴化异丙托品、沙丁胺醇联合雾化吸入对慢性阻塞性肺病急性加重期的疗效观察

The Effect Observations of Nebulizations of Ipratropium Bromid Plus Salbutamol on Acute Exacerbations Of Chronic Obstructive Pulmonary Disease

目的:探讨联合雾化吸入溴化异丙托品、沙丁胺醇治疗慢性阻塞性肺疾病(COPD)急性加重期的疗效。方法:60例COPD急性加重期患者随机分为对照组和治疗组。两组均给予抗感染、吸氧、氨茶碱静脉注射及对症等治疗,治疗组加用溴化异丙托品、沙丁胺醇联合雾化吸入。比较两组治疗前和治疗后2h的1s用力呼气容积(FEV1)、FEV1占用力肺活量(FVC)百分比(FEV1/FVC)及动脉血气分析的变化。结果:治疗后,两组肺功能及动脉血气较治疗前均有明显改善(P<0.05),治疗组与对照组比较,FEV1、FEV1/FVC、PaO2和PaCO2差异显著(P<0.05)。结论:联合雾化吸入溴化异丙托品、沙丁胺醇治疗慢性阻塞性肺疾病(COPD)急性加重期的疗效显著。

Objective： To investigate the treatment effect of nebulizations of ipratropium bromid plus salbutamol on acute exacerbations of chronic obstructive pulmonary disease （COPD）. Methods： 60 patients with acute exacerbations of COPD were randomly divided two groups （the treatment group and the control group）. The basic regiments for the two groups were oxygen, antibiotics, aminophyUine, and the treatment group was given ipratropium bromid and salbutamol by nebulizer. All patients underwent pulmonary function test and arterial blood gas analysis before treatment and 2 hour after therapy. Results： There were significant improvement of all pulmonary function and arterial blood gas relevant parameters of two groups after therapy （P 〈 0.05）. after therapy, FEV1、FEV1/FVC.PaO2 and PaCO2 were much higher in the treatment group than in the control group （P 〈 0.05）. Conclusion： They were markedness that the treatment effect of nebulizations of ipratropium bromid plus salbutamol on acute exacerbations of COPD.