1Douillard JY, Hoff PM, Skillings JR, et al. Muhicenter phase Ⅲ study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic coloreetal cancer. J Clin Oncol,2002,20( 17 ) :3605-3616.
2Carmichael J, Popiela T, Radstone D, et al. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol,2002, 20(17) :3617-3627.
3Feliu J, Vicent JM, Garcia Giron C, et al, Phase Ⅱ study of UFT and oxaliplatin in first-line treatment of advanced colorectal cancer. Br J Cancer,2004,91 (10) :1758-1762.
4Schoffski P. The modulated oral fluoropyrimidine prodrug S- 1, and its use in gastrointestinal cancer and other solid tumors. Anticancer Drugs,2004,15 (2) :85-106.
5Hoff PM,Saad ED,Ajani JA,et al. Phase Ⅰ study with pharmacokinetics of S- 1 on an oral daily schedule for 28 days in patients with solid tumors. Clin Cancer Res,2003,9(1) :134-142.
6Van den Brande J,Schoffski P, Schellens J H, et al. EORTC Early Clinical Studies Group early phase Ⅱ trial of S-1 in patients with advanced or metastatic colorectal cancer. Br J Cancer,2003,88(5 ) :648-653.
7Schilsky RL, Levin J, West WH, et al. Randomized, open-label, phase Ⅲ study of a 28-day oral regimen of eniluracil plus fluorouracil versus intravenous fluorouracil plus leucovofin as first-line therapy in patients with metastatic/advanced colorectal cancer. J Clin Oncol,2002,20(6 ) :1519-1526.
8Hoff PM, Cassidy J, Schmoll HJ. The evolution of fluoropyrimidine therapy : from intravenous to oral. O neologist, 2001,6 ( Suppl 4 ) : 3 - 11.
9Bajetta E,Colleoni M, Di Bartolomeo M, et al. Doxifluridine and leucovorin: an oral treatment combination in advanced colorectal cancer. J Clin Oneol,1995,13(10) : 2613-2619.
10Ahn JH, Kim TW, Lee JH, et al. Oral doxifluridine plus leucovorin in metastatic colorectal cancer: randomized phase Ⅱ trial with intravenous 5-fluorouracil plus leucovorin. Am J Clin Oncol, 2003,26 ( 1 ) :98-102.
