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雄激素与男性冠心病的关系 被引量:3

Relationship between androgens and coronary heart disease in men
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摘要 雄激素与男性冠心病的关系存有较多争议,但多数研究发现雄激素有抗动脉粥样硬化的作用,男性雄激素水平的降低与冠心病的发生密切相关。雄激素通过影响人体的脂质代谢、凝血纤溶系统、血管张力及血管内皮功能对抗男性冠心病的形成和发展。 The relationship between androgens and Coronary Heart Disease(CHD) in men remains controversy, but considerate studies show androgens exert beneficial effects on atherosclerotic progression. The development of CHD in men is closely associated with low endogenous androgens levels. Through its effect on the risk factors of cardiovascular diseases, such as lipid metabolism, hemostatic and fibrinolytic system, vascular reactivity and vascular endothelium function, androgens protect against the development of CHD in men.
出处 《国际内分泌代谢杂志》 2006年第B04期23-26,共4页 International Journal of Endocrinology and Metabolism
关键词 雄激素 睾酮 动脉粥样硬化 冠心病 Androgens Testosterone Atherosclerosis Coronary heart disease
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参考文献24

  • 1English KM, Mandour O, Steeds RP, et al, Men with coronary ,artery disease have lower levels of androgens than men with normal cometary angiograms. Eur Heart J, 2000,21:890-894.
  • 2Hak AE,Witteman JC,de Jong FH,et al. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study, J Clin Endocrinol Metab, 2002,87 :3632-3639.
  • 3van den Beld AW, Bots ML, Janssen JA, et al, Endogenous hormones and carotid atherosclerosis in elderly men, Am J Epidemiol, 2003, 157: 25-31.
  • 4Muller M, van der Schouw YT, Thijssen JII, et al. Endogenous sex hormones and cardiovascular disease in lnen. J Clin Endocrinol Metab,2003,88: 5076-5086.
  • 5Wu FC,von Eckardstein A. Androgens and coronary artery disease. Endoer Rev,2003,24:183-217.
  • 6Schatzl G, Madersbaeher S, Temml C, et al. Serum androgen levels in men: impact of health status and age. Urology,2003,61:629-633.
  • 7Van Pottelbergh I, Braeckman L, De Bacquer D, et al. Differential contribution of testosterone and estradiol in the determination of cholesterol and lipopmtein profile in healthy middle-aged men. Atherosclerosis,2003,166:95-102.
  • 8lsidori AM, Giannetta E, Greco EA, et al, Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol, 2005,63 : 280-293.
  • 9Malkin CJ, Pugh PJ, Jones RD, et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab,2004,89: 3313-3318.
  • 10Anawalt BD, Herbst KL, Matsumoto AM, et al. Desogestrel plus testosterone effectively suppresses spermatogenesis but also causes modest weight gain and high-density lipopmtein suppression, Fertil Steril,2000,74:707-714.

二级参考文献20

  • 1Hamsten,A,Eriksson P.Fibrinolysis and atherosclerosis[J].Baillieres Clin Haematol,1995,8(2):345-363.
  • 2Ganti AK,Potti A,Yegnanarayan R.Plasma tissue plasminogen ctivator and plasminogen activator inhibitor-1 levels in acute myocardial infarction[J].Pathophysiol Haemost Thromb.2002,32(2):80-84.
  • 3Saed GM,Diamond MP.Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritomeal and adhesion fibroblasts[J].Fertil Sterol,2003,79(1):164-168.
  • 4Sullivan ML,Martinex CM,Gennis P,et al.The cardiac toxicity of anabolic steroids[J].Prog Cardiovasc Dis,1998,41(1):1-15.
  • 5Zhu Y,Farrehi PM,Fay WP.Plasminogen activator inhibitor type-1 enhances neointima formation after oxidative vascular injury in atherosclerosis-prone mice[J].Circulation,2001,103(25):3105-3110.
  • 6Death AK,MaGrath KG,Sader MA,et al.Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-kappa B-Dependent pathway[J].Endocrinology,2004,145(4):1889-1897.
  • 7Pugh PJ,Channer KS,Parry H,et al.Bio-available testosterone levels fall acutely following myocardlial infarction in men;association with fibrinolytic factors[J].Endocr Res ,2002,28(3):161-173.
  • 8Smith AM,English KM,Malkin GJ,et al.Testosterone does not adversely affect fibrinogen or tissue plasminogen activator(IPA)and plasminogen activator inhibitor-1(PAI-1) levels in 46 men with chronic stable angina[J].Eur J Endocrinol,2005,152(2):285-291.
  • 9Ling S,Dai A,Williams MR,et al. Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells [J].Endocrinology,2002,143(3):1119-25.
  • 10Hanke H,Lenz C,Hess B,et al. Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall[J]. Circulation,2001,103(10):1382-5.

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