黄酮类化合物的潜在毒性作用

Advances in studies on potential toxicity of flavonoids

黄酮类化合物,包括黄酮、黄酮醇、黄烷酮、异黄酮、双黄酮、查尔酮等,广泛存在于膳食及植物中。大量研究表明,黄酮类化合物具有抗氧化、清除自由基、抗癌、抑菌、消炎等功效,多年来黄酮类医药制剂已广泛应用于心脑血管疾病和癌症治疗,近年来黄酮类保健食品也发展很快。文章综述了国内外各类黄酮类化合物的毒理学研究进展,为合理应用黄酮类化合物提供一定的科学依据。

Flavonoids, inclading flavones, flavonols, anthocyanins, flavanones, chalcones, flavan, proanthocyanidins, isotlavonoids and hiflavonoids, etc, are natral components in our diet and plants.Several beneficial properties have been attributed to these compounds,including antioxidant, anti-inflammatory and anticarcinogenic effects, etc. Flavonoid preparations are marketed as herbal medicines or dietary supplements for a variety of alleged nontoxic therapeutic effects. However, they have yet to pass controlled clinical trials for efficacy, and their potential for toxicity is an understudied field of research. This review summarizes the current studies on the toxicity induced by flavonoids and gives some advices for ingesting flavonoids.