萝卜秦艽化学成分的研究Ⅰ

Studies on chemical constituents in root of Phlomis medicinalis Ⅰ

目的:研究萝卜秦艽的化学成分。方法:采用大孔树脂、薄层色谱、硅胶柱色谱和制备高效液相色谱进行分离纯化,通过理化方法和波谱数据进行结构鉴定。结果:从95%乙醇提取物大孔树脂40%乙醇洗脱物中分离并鉴定了8个化合物,分别为5-羟基-7-甲氧基-4,6-二甲基-2-苯并呋喃酮(1),4-羟甲基-2-糠醛(2)和6个环烯醚萜苷类化合物6-乙酰基山栀苷甲酯(3),8-乙酰基山栀苷甲酯(4),山栀苷甲酯(5),sesamoside(6),phloyosideⅡ(7)和dehydropentstemoside(8)。结论:所有化合物均为首次从该植物中分得,其中化合物1和3为首次从该属植物中分得。

Objective： To study the chemical constituents in root of Phlomis medicinalis. Method： The compouds were isolated and repeatedly purified on macroporous resin, silica gel colunm chromatography, TLC and Prep-HPLC and the structures were elucidated by physico-chemical properties and NMR spectra. Result： Eight compounds were obtained and elucidated as 5-Hydroxy-7-methoxy-4, 6-dimethy]ph- thalide （1）, 4-hydroxymethyl-2-furaldebyde （2） and six iridoid glucosides： 6- O- acetyl-shenzhislde methyl ester （3）, 8- O-acetyl-aharzhiside methyl ester （4）, shanzhislde methyl ester （5）, sesamoside （6）, pldoyoside Ⅱ （7） and dehydropentstemoside （8）. Conchusion： All the eompotmds were isolated from the plant for the first time and 1 and 3 were obtained from the plants of Phiomis for the first time.