祛毒冲剂治疗肠源性内毒素血症的临床研究

Clinical research on treatment of enterogenous endotoxemia with Qudu medicinal granules (祛毒冲剂)

目的:观察祛毒冲剂对危重病肠源性内毒素血症的治疗价值。方法:61例肠源性内毒素血症患者随机分为祛毒冲剂组(30例)和思密达组(31例),在治疗前,治疗后1、3和7d分别观测、记录患者一般体征变化,清晨空腹采外周静脉血测定白细胞计数、血浆内毒素及血清肿瘤坏死因子(TNF)水平。结果:祛毒冲剂组外周血白细胞计数下降速度明显快于思密达组,3d后差异有显著性(P<0.01),排便次数多于思密达组(P=0.000),并可较快地降低血浆内毒素及血清TNF水平(P均<0.01)。结论:祛毒冲剂可以有效地降低血浆内毒素及血清TNF水平,并改善患者的临床症状,促进患者康复。

Objective： To observe the role of Qudu medicinal granules （祛毒冲剂） on enterogenous endotoxemia. Methods： Sixty-one cases with enterogenous endotoxemia were randomly divided into two groups：Qudu medicinal granule group （n=30） that was treated with Qudu medicinal granules combined with western medicine, and smecta group which was treated with smecta and western medicine （n=31 ）. Changes of symptoms and signs were observed before treatment and 1, 3, 7 days after treatment. Blood samples were collected in the morning to measure the white blood cell （WBC）, plasma lipopolysaccharide （LPS） and tumor necrosis factor （TNF） levels. Results： Recovery speed of WBC count in Qudu medicinal granule group was faster than that of the smeeta group, there was significant difference on the third day after treatment （P〈0. 01）; while the defecation frequency was higher （P=0. 000）, and levels of plasma LPS and TNF were eliminated more rapidly than that of the smecta group （all P〈20.01）. Conclusion： Qudu medicinal granules could effectively reduce the levels of plasma LPS and TNF, and improve clinical outcome.