脑梗死患者血清IL-6水平的变化

Changes of Serum IL-6 Levels in Patients with Acute Cerebral Infarction

目的:观察急性脑梗死(CI)患者血清白介素-6(IL-6)水平的变化,并探讨其临床意义。方法:采用放射免疫分析检测39例急性CI患者发病后1d、3d、7d的血清IL-6水平,并按病灶大小和病情轻重分组比较。结果:CI患者血清IL-6含量在1d、3d均高于对照组(P<0.01),而第7d两组比较无显著性差异(P>0.05);大、中梗死灶组血清IL-6水平显著高于小梗死灶组。结论:急性CI患者病后血清IL-6水平显著增高,血清IL-6升高的程度与脑梗死体积的大小和神经功能受损程度密切相关。

Objective To investigate the clinical significance of changes of serum IL - 6 levels in patients with acute cerebral infarction （CI）. Methods Serum IL- 6 levels were measured with RIA in 39 patients with acute CI on d 1, d3, d7 after onset of the disease as well as in 34 controls. Results The levels of serum IL -6 in patients with acute CI were significantly higher than those in controls on dl and d3 （P 〈0.01 ）, but the levels on d7 were not significantly different from those in controls （P 〉 0.05）. Among the patients, the levels in patients with large （over 10cm3, n = 13） and medium （4～10cm^3, n = 11 ） sized lesions were significantly higher than those in patients with small （ 〈4cm^3） sized lesions. Conclusion Serum levels of IL -6 increased markedly in patients with acute CI and the magnitude of the elevation was closely related ot the size of lesion and degree of neurological impairment.