急性脑梗死患者治疗前后血清NSE、血浆NPY水平检测的临床意义

Clinical Significance of Measurement of Changes of Serum NSE and Plasma NPY Levels After Treatment in Patients with Acute Cerebral Infarction

目的:探讨了急性脑梗死患者血清神经元特异性烯醇化酶(NSE)和血浆神经肽Y(NPY)水平的变化及临床意义。方法:应用放射免疫分析对38例急性脑梗死患者进行了血清NSE和血浆NPY水平测定,并以35名正常健康人作比较。结果:急性脑梗死患者血清NSE和血浆NPY水平非常显著地高于正常人组(P<0.01),经治疗3个月后血清NSE和血浆NPY仍有差异(P<0.05)。结论:急性脑梗死患者血清NSE和血浆NPY水平的变化与急性脑梗死的发病机理有密切的关系。

ebral infarction. Methods Serum NSE and plasma NPY levels were measured with RIA in 38 patients with acute cerebral infarction both before and after treatment as well as in 35 controls. Results Before treatment in the patients the serum NSE and plasma NPY levels were significantly higher than those in controls （P 〈0.01 ）. After three months＇ treatment the levels dropped markedly but remained significantly higher than those in controls （P 〈 0.05）. Conclusion Serum NSE and plasma NPY levels changes were closely related to the progress of acute cerebral infraction.