急性脑梗死患者血清TNF-α和CRP的变化及临床意义

Clinical Significance of Changes of Plasma TNF-α and CRP Levels in Patients with Acute Cerebral Infarction

目的:探讨急性脑梗死患者血清肿瘤坏死因子(TNF-α)和C-反应蛋白(CRP)的变化及临床意义。方法:随机选择50名急性脑梗死患者采用放射免疫分析测定血清TNF-α含量,采用散射速率免疫比浊法测定血清CRP含量,62名健康人作为对照组。结果:脑梗死患者急性期血清TNF-α和CRP水平均显著高于健康对照组(P<0.01),且与梗死灶面积呈正相关(P<0.05)。结论:急性脑梗死患者早期血清TNF-α和CRP变化与脑梗死的临床表现密切相关。

Objective To investigate the clinical significance of the changes of serum TNF -α and CRP levels in patients with acute cerebral infarction. Methods Serum TNF-α （with RIA） and CRP （with scatter velocity turbidimetry） levels were determined in 50 patients with acute cerebral infarction and 62 controls. Results The serum levels of TNF -α and CRP in patients with acute cerebral infarction were significantly higher than those in controls （P 〈0.01 ）. Moreover, the levels were positively correlated with the size of the infarction （P 〈 0.05）. Conclusion Changes of serum TNF -α and CRP levels during acute stage of cerebral infarction were closely related the clinical progression of the disease process.