脑血管病患者血清Hcy和IGF-Ⅱ测定的意义

Significance of Determination of the Serum Levels of Homocysteine (Hcy) and Insulin-Like Growth Factor-Ⅱ (IGF-Ⅱ) in Patients with Cerebrovascular Diseases

目的:探讨脑血管病(CVD)患者血清同型半胱氨酸(Hcy)和胰岛素样生长因子Ⅱ(IGF-Ⅱ)变化及其临床意义。方法:123例CVD患者(其中脑梗死69例,脑出血54例)和43例对照组血清分别用化学发光法测定其Hcy水平和放射免疫分析测定其IGF-Ⅱ水平,并进行统计分析。结果:脑血管病患者其Hcy和IGF-Ⅱ水平较对照组均有明显升高(P<0.01,P<0.01),脑梗死(CI)组与脑出血(CH)组比较Hcy和IGF-Ⅱ水平无明显差异(P>0.05)。结论:CVD患者血清Hcy和IGF-Ⅱ水平升高,可能两者共同参与了CVD的发生和发展。

Objective To investigate the clinical significance of the changes of homocysteine （Hcy） and insulin - like growth factor Ⅱ （IGF -Ⅱ） in patients with cerebrovascular diseases （CVD）. Methods The serum Hey （with CLIA） and IGF -Ⅱ （with RIA） levels were measured in 123 patients with CVD （cerebral infarction 69 and cerebral hemorrhage 54） and 43 controls. Results The levels of Hcy and IGF-Ⅱ in patients with CVD were significantly higher than those in the controls （P 〈0. 01, P 〈0.01 ）. The serum Hcy and IGF-Ⅱ levels in patients with cerebral infarction （CI） were not significantly different from those in patients with cerebral hemorrhage （CH） （P 〉 0.05）, Conclusion The serum Hcy and IGF-Ⅱ levels in patients with CVD are elevated, Hcy and IGF-Ⅱ may be in- volved in the development and pathogenesis of CVD.