肝硬化患者胰岛素样生长因子变化及意义

Clinical Significance of Changes of Serum Insulin-Like Growth Factors Contents in Patients with Cirrhosis of Liver

目的:探讨肝硬化患者胰岛素样生长因子Ⅰ、Ⅱ变化与肝功能Child-pugh分级关系及意义。方法:肝硬化患者46例,按Child-pugh分级分为A、B、C三组;正常对照组32例。分别测定他们的肝功能、IGF-Ⅰ、IGF-Ⅱ值。比较正常组与不同Child-pugh级别中肝硬化患者的IGF-Ⅰ、IGF-Ⅱ变化。结果:肝硬化患者IGF-Ⅰ、IGF-Ⅱ较正常组明显降低(P<0.001),IGF-Ⅱ的敏感性高于IGF-Ⅰ,联合测定有协同评估肝功能及提示预后的作用。结论:肝硬化患者IGF-Ⅰ、IGF-Ⅱ可作为病情及预后评估重要指标。

Objective To investigate the association between the serum contents of IGF - Ⅰ , IGF - Ⅱ and liver dysfunction （as classificd with Child -Pugh grades）. Methods Liver function test profiles as well as serum IGF- Ⅰ , IGF - Ⅱ contents （with IRMA） were studied in 46 patients with liver cirrhosis and 32 controls. Results According to the degree of liver dysfunction, these 46 patients with cirrhosis could be classitfied as： Child Grade A, n =17; Child B, n =20; and Child C, n =9. The serum IGF - Ⅰ and IGF - Ⅱ contents in the cirrhotic patients were significantly lower than those in the controls （P 〈 0. 001 ）. The levels dropped along with the progression of child classification grades. Changes of IGF - Ⅱ were more sensitive than those of IGF - Ⅰ. Conclusion Serum IGF - Ⅰ and IGF - Ⅱ contents were closely associated with degree of liver dysfunction and might be of prognostic significance.