美托洛尔对充血性心力衰竭患者心功能的影响

The Effect of Metoprolol on Cardiac Function in Patients with Congestive Heart Failure

目的:观察美托洛尔对应用血管紧张素转化酶抑制剂等基础治疗的充血性心力衰竭患者心功能影响,探讨其治疗充血性心力衰竭的机制。方法:对NYHAⅡ-Ⅳ级充血性心力衰竭患者在常规治疗基础上加用美托洛尔,起始剂量12.5mgd/,如能耐受逐渐加量至最大耐受量。结果:两组间心率、血压、心功能、左室射血分数、短轴缩短率差异有显著意义(P<0.05)结论:单纯血管紧张素转化酶抑制剂等基础治疗仍存在神经内分泌的激活,美托洛尔可抑制神经内分泌的激活,同时伴LVEF的升高。

Objective： To study changes of cardiac function during metoprolol therapy in patients with congestiw.＇ heart failure（CHF）, Methods： Engity-two patients with congestive heart failure （New York Heart Association functional class Ⅱ- Ⅳ ） were treated with carvedilol at the beginning does of 12.5regal and was slowly titrated to 150mg/d as tolerated or the dose can be just tolerated. At the same time, adverse events was evaluated. Results： both groups had significant differences （P〈0.05） Conclusion： There still exists activation of neuroendocrine during ACEI medication in CHF patients, and it can be suppressed by administration of metoprolol and in the meantime, LVEF was elevated.