咽喉舒胶囊的药效学研究

Studies on Pharmacodynamics of Yan Hou Shu Capsule

目的观察中药复方咽喉舒胶囊的主要药效作用。方法运用毛细管方法及浓氨水引咳法分别观察咽喉舒胶囊的祛痰止咳作用。运用小鼠耳廓肿胀、大鼠足跖肿胀模型及腹腔注射醋酸方法,评价咽喉舒胶囊的抗炎消肿作用及对毛细血管通透性的影响。采用25%氨水造模的SD大鼠急性咽炎模型,从病理组织学的角度评价咽喉舒胶囊抗急性咽炎作用。结果整体实验咽喉舒胶囊设低、中、高3个剂量组(大鼠分别为0.45、0.9、1.8g·kg-1;小鼠分别为0.9、1.8、3.6g·kg-1)。本品高、中剂量显著增加大鼠的排痰量、延长咳嗽潜伏期并减少咳嗽次数。本品呈剂量依赖性显著减轻二甲苯引起的小鼠耳廓肿胀,减轻大鼠足跖肿胀度并降低小鼠腹腔毛细血管通透性。结论咽喉舒胶囊具有抑菌、止咳祛痰和抗炎消肿作用,有利于咽炎的防治。

Aim To study the main pharmacodynamics of Yan Hou Shu Capsule （YHSC）. Methods The YHSC＇s expectorant and antitussive effects were evaluated by capillary test in rats and thick ammonia-induced cough in mice. The anti-inflammatory and detumecent effects were investigated by dimethylxylene-caused mouse ear swelling, carrageeninchallenged paw edema and the permeability of abdominal capillary by injecting glacial acetic acid in mice, respectively.The inhibitory effect of YHSC on acute pharyngitis induced ammonia was evaluated by pathohistology in SD rats. Results In vitro test, the low-, middle-, high-dose of YHSC （0.45,0.9,1.8g·kg^-1 for rats and 0.9,1.8,3.6g·kg^-1 for mice）was designed. The high- and middle-dose of YHSC significantly increased the phlegm exudation of rats and pronlonged the latent period and the frequence of cough induced by thick ammonia in mice. YHSC lightened the dimethylxylene-caused mouse ear swelling, carrageenin-challenged paw edema in rats and the permeability of capillary, in a dose-dependent manner. YHSC decreased the permeability of abdominal capillary in mice. The pathological changes were significant in the pharyngitis model as compared with the normal group. The middle and high dose of YHSC significantly improved the pathologic changes in a dose-depended manner. Conclusion YHSC had expectorant, antitussive, as well as significant antiinflammatory effect. YHSC can help the prevention and therapy of pharyngitis.