Axin研究进展

Progress in Axin

Axin作为一种多功能的支架蛋白参与了多种生理病理过程,涉及到胚胎发育、肿瘤形成、细胞凋亡、糖原代谢等过程,至少在Wnt信号转导通路、应激反应蛋白激酶(SAPK)信号通路、转化生长因子β(TGFβ)信号通路和胰岛素信号转导通路中扮演着重要的角色。对Axin的研究将有助于对胚胎发育、肿瘤形成等重要的生物学问题进一步了解,同时对细胞信号调控网络有一个新的认识。现从Axin在相关疾病、代谢及主要细胞信号通路中的作用等方面对其研究进展做一综述。

As a multifunctional scaffold protein, Axin participates in many kinds of physiological and pathological processes, including embryo development, carcinogenesis, cell apoptosis and glycogen metabolism etc., and plays important roles at least in Wnt signaling pathway, SAPK signaling pathway, TGFβ signaling pathway and insulin signaling pathway. The investigation of Axin will be help to figure out the important biological problems such as embryo development and carcinogenesis, and provide new insights into the signaling transduction and its regulatory net. This review is to focus on recent developments of the effects of Axin on diseases, metabolism and especially on cell signaling transduction pathway.