纺锤体组装检控点

Spindle Assembly Checkpoint

细胞有丝分裂过程中,纺锤体组装检控点监控着染色体在赤道板的队列和向纺锤体两极的分离,确保动粒-微管的黏附和有丝分裂器的完整,使所有的染色体都置于赤道板并双极定向后才进入后期,保证遗传物质均等地分配给两个子代细胞。纺锤体组装检控点缺陷将导致非整倍体的出现,并与一些肿瘤的发生密切相关。现就近年来纺锤体组装检控点蛋白以及纺锤体组装检控点功能缺陷与肿瘤的关系方面的研究进展作一简要综述。

Chromosomes aligned to the metaphase plate and segregated to the mitotic spindle are regulated by the spindle assembly checkpoint. This surveillance mechanism monitors kinetochore-microtubule attachment and the integrity of the mitotic apparatus, and is able to delay the metaphase-anaphase transition until all chromosomes are properly aligned at the metaphase plate and established a bipolar orientation, ensuring equal segregation of genomic material among daughter cells. Functional defects in spindle assembly checkpoint can generate gross aneuploidy and are associated with tumorigenesis. In this review, we will focus on the molecular components of spindle assembly checkpoint pathway and the relationship between the function defects of this checkpoint and tumorigenesis.