三维适形放疗联合XELOX方案治疗局部晚期和术后复发性直肠癌

Three dimensional-conformal radiotherapy combined with oxaliplatin and capecitabine chemotherapy for locally advanced colorectal cancer

目的:观察三维适形放疗加卡培他滨联合奥沙利铂化疗(XELOX方案)治疗局部晚期和术后复发性直肠癌的临床疗效及毒副反应。方法:经病理或细胞学证实的局部晚期和术后复发性直肠癌患者25例,每天口服卡培他滨2000mg/m2,d1～d14,静滴奥沙利铂130mg/m2,d1。每3周为1个治疗周期,全组共完成119周期。同步放疗为先三野同中心全盆腔放疗40Gy,后针对局部肿瘤病灶行三维适形放疗加量至60Gy。结果:25例患者中CR16%,PR64%,NC12%,PD8%,总有效率为80%,主要不良反应为消化道反应及感觉神经病变,未见大于Ⅲ级的毒性反应。结论:三维适形放疗加XELOX方案化疗治疗局部晚期和术后复发性直肠癌疗效确切,毒副反应小,是有效治疗晚期大肠癌的新方案。

Objective：To determine the efficacy and toxicities of three dimensional-conformal radiotherapy combined with oxaliplatin and capecitabine chemotherapy for locally advanced colorectal cancer. Methods：25 patients with advanced colorectal cancer were treated with oxaliplatin 130 mg/m^2 on day 1 and capecitabine 2 000mg/m^2 daily in two divided doses on days 1 - 14 every 3 weeks combined with three dimensional-conformal radiotherapy. Results：The overall response rate was 80%, with a complete response rate of 16%. There were no treatment-related death and no grade 4 haematological toxicity. Conclusion： Three dimensional-conformal radiotherapy combined with oxaliplatin and capecitabine chemotherapy are active in advanced colorectal cancer. It can result in down-staging of tumours. In addition, it is a well-tolerated regimen.