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药物成瘾性脑病立体定向手术靶点选择及机理 被引量：1

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摘要 成瘾药物主要作用于脑内特殊奖赏系统,涉及多巴胺(dopamine DA)、阿片肽、r氨基丁酸(gammaaminobutyricacid GABA)等递质系统;作用部位主要集中在腹侧被盖区(ventraltegmentalareaVTA)、伏核(nucleus accumbensNAc)、扣带回等,导致这些部位出现功能和结构变化。立体定向手术主要是破坏成瘾产生的相关结构和环路及成瘾记忆而产生治疗作用。
作者 王林 钱若兵 傅先明
机构地区 安徽医科大学附属省立医院神经外科
出处 《国际神经病学神经外科学杂志》 2006年第2期197-200,共4页 Journal of International Neurology and Neurosurgery
基金 安徽省自然科学基金项目 课题编号:050430708
关键词 药物成瘾 立体定向术 靶点 药物成瘾性脑病 手术靶点
分类号 R651.1 [医药卫生—外科学]
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参考文献21

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同被引文献11

  • 1胡永生,李勇杰,石长青,张宇清,朱宏伟,马凯,张晓华.脑立体定向止痛手术治疗中枢性疼痛[J].中国疼痛医学杂志,2005,11(4):197-200. 被引量：20
  • 2Nurmikko TJ . Mechanisms of central pain[J]. Clin J Pain, 2000 , 16(2) : 21 -25.
  • 3Cruceu G, Aziz TZ, Garcia--Larrea L, et al. EFNS guidelines on neurostimulation therapy for neuropathic pain[J]. Eur J Neurol, 2007,14(9) :9524970.
  • 4Meyerson BA. Neurosurgical approaches to pain treatment [J]. Acta Anaesthesiol Seand, 2001, 45:1108-1113.
  • 5Zahm DS, Heimer L. Specificity in the efferent projections of the nucleus accumbens in the rat: comparison of the rostral pole projection patterns with those of the core and shell[J]. J Comp Neurol, 1993, 327(2): 220-232.
  • 6Tod EK, Veneta S, Julia B, et al. Opposing roles of the nucleus accumbens and anterior lateral hypothalamic area in the control of sexual behaviour in the male rat[J]. European Journal of Neuroscience, 2004, 19(3) :698-704.
  • 7Altier N, Sewart J. The role of dopamine in the nucleus accumbens in analgesia[J]. Life sciences, 1999,65 (22) : 2269 -2287.
  • 8Bush G, Vogt BA, Hdmes J, et al. Dorsal anterior cingulate cortex: A role in reward--based decision making [J]. PNAS, 2002, 99(1): 523-528.
  • 9Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus[JJ. Nature Reviews Neuroscience, 2005, 6(7): 533-544.
  • 10Wilkinson HA, Davidson KM, Davidson RI. Bilateral anterior cingulotomy for chronic noncancer pain[J]. Neurosurgery, 1999,45 : 1129 - 1136.

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国际神经病学神经外科学杂志
2006年 第2期

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