摘要
目的建立高效液相色谱法测定瑞舒伐他汀钙含量的方法。方法色谱柱:KromasilC18色谱柱(4.6mm×250mm,5μm);检测波长:242nm;流动相:乙腈0.3%草酸铵溶液(醋酸调节pH4.0)(42∶58);流速:1.0ml·min-1。结果在10～500μg·ml-1内有良好的线性关系,相关系数为0.9999,精密度小于1.0%(n=6)。结论本方法简便、准确,可用于瑞舒伐他汀钙及其片剂的含量测定。
AIM To establish a HPLC method for the determination of rosuvastatin calcium. METHOD6 The seperafion was accomplished on a Kromasil Cl8 column（4.6 mm ×250 mm,5 μm）. The detection wavelength was at 242nm. The＇mobile phase consisted of acetonitrile and 0.3% ammonium oxalate solution （adjusted to pH 4.0 with acetic acid）（42：S8）. RESULTS A good linear relationship was abtained over the range of 10-500μg·ml^-1（r=0.9999）. The RSD was less than 1.0%（n=6）. CONCLUSION The method is accurate and easy for the measurement of the content of rosurastaion calcium.
出处
《江苏药学与临床研究》
2006年第2期97-100,共4页
Jiangsu Pharmacertical and Clinical Research
