长春七提取物镇痛作用的实验研究

Experimental studies on analgesic effect of the extractions of Libanotis buchtormensis.

目的研究长春七提取物的镇痛作用。方法采用醋酸致小鼠扭体反应及小鼠热板法进行镇痛实验研究。结果长春七70%乙醇提取物和乙醚提取物可显著抑制醋酸所致小鼠扭体反应及提高热板法所致小数痛觉反应的痛阈,作用强度与剂量有关。结论长春七70%乙醇提取物和乙醚提取物有较好的镇痛作用。

OBJECTIVE To study the analgesic effect of the extractions of Libanotis buchtormensis （Fisch） DC.. METHODS The analgesic effect was studied by using acetic acid - induced wringing text and hot plate text in mice. RESULTS The frequency of wringing reaction was redused by the extractions of ether and 70% ethanol of Libanotis buchtormensis （Fisch） DC.. Meanwhile, these extractions obviously restrained the wringing reaction induced by acetic acid and evaluated pain threshold of the mice on the hot plate, and their intensity was related to the dose. CONCLUSION The extractions of ether and 70% ethanol of Libanotis buchtormensis （Fisch） DC. possess significant analgesic effect.