卵巢癌患者治疗前后血清CA125、TGFα和TNFα联检的临床意义

Clinical Significance of Combined Determination of the Changes of Serum CA125,TGFα and TNFα Levels After Operation in Patients with Ovarian Cancer

【目的】探讨卵巢癌患者血清中CA125、生长转化因子-α(TGFα)和肿瘤坏死因子α(TNFα)水平的变化及临床意义。【方法】应用放射免疫分析检测30名卵巢癌患者TGFα和TNFα含量和采用酶联免疫法同时检测CA125含量,并与30名卵巢良性肿瘤患者和30名正常健康人作比较。【结果】治疗前卵巢癌患者血清中CA125和TGFα、TNF水平显著高于正常人组(P<0.01)。治疗后1个月复测其水平皆已接近正常。术后6个月再测,未复发者仍属正常水平,而复发者又恢复至治疗前水平。【结论】测定卵巢癌患者血清中CA125、TGFα、TNFα水平对评估患者的治疗和预后均有十分重要的临床价值。

[Objective] To investigate the clinical significance of changes of serum CA125, TGFα and TNFα levels after operation in patients with ovarian cancer. [Methods] Serum levels of cancer antigen 125 （CA125）and transforming growth factor-α（TGFα）, tumor necrosis factor-α（TNFα） were repeatedly determined in 30 patients with ovarian cancer,30 patients with ovarian neoplasm （the benign group） and 30 healthy subjects （the normal group） before operation, 1 month after operation and 6 months after operation as well as in 30 controls. [Results]Before operation serum levels of CA125 and TGFα, TNFα were significantly higher than those in the controls（ P 〈0.01）. One month after operation, all the serum levels were approaching normal. Six months later, the levels in the patients without recurrence remained normal. However, the levels in 9 patients with recurrence returned to preoperative ones again. [Conclusion]Changes of serum CA125, TGFα and TNFα levels are closely related to the tumor burden and may reflect the presence of recurrence.