CD68及IGF-1在鼻息肉中的表达及其意义

The Expression and Significance of CD68 and IGF-1 in Nasal Polyps

【目的】探讨CD68及胰岛素样生长因子-1(IGF-1)在鼻息肉中的表达及其相关关系以分析其在鼻息肉发病中的作用。【方法】采用免疫组化SP法分别检测30例鼻息肉、20例中鼻甲黏膜组织中CD68及IGF-1表达情况。【结果】①鼻息肉组织中CD68及IGF-1水平均明显高于中鼻甲黏膜组织(P均<0.01)。CD68阳性细胞主要位于黏膜下组织间隙,IGF-1阳性细胞主要集中于鼻息肉的黏膜上皮细胞、囊性扩张的腺体细胞及炎性细胞中。②鼻息肉组织中CD68与IGF-1呈明显正相关关系,相关系数r=0.843,P<0.01。【结论】鼻息肉中细胞增殖活跃,尤其是上皮细胞、腺体细胞和组织中浸润的炎性细胞较正常明显增加。细胞增殖活跃在鼻息肉的形成和复发中起重要作用,而炎症反应则为上皮细胞增生的主要原因。

[Objective]To explore the expression of CD68 and IGF-1 in nasal polyps and their roles in the pathogenesis of nasal polyps. [Methods]Thirty patients with nasal polyps and 20 control cases were chosen. All samples were stained with SP and immunohistochemical method to examine CD68 and IGF-1 respectively. [Results]①The level of CD68 and IGF-1 in nasal polyps was all significantly higher than that in normal control specimens （ P d0. 01）. CD68 expressed in submucous tissue , and IGF-1 expressed in epithelium and inflam- mation cells.②The positive correlation of CD68 and IGF-1 was significant （r = 0. 843, P 〈 0. 01）. [Conclusion]Cell proliferations are active in nasal polyps, especially in epithelium mucosae,glandular epithelium and inflammtion cells, play an important role in the pathogenesis of nasal polyps.