类胡萝卜素的抗癌作用与基因表达的联系

The anticancer effects of carotenoids and gene expression

类胡萝卜素是通过干扰癌细胞生长或细胞死亡的有关途径显示其抗癌作用的,包括细胞增殖、生长因子的信号传输、细胞间隙连接通讯、细胞分化及凋亡。类胡萝卜素引起参与这些过程的调节蛋白质表达发生改变。已发现几个转录系统在其抗癌活性中起作用,如类视黄素受体、过氧化物酶体激活受体(PPAR)、抗氧化剂应答元件(ARE)、异生素受体及激活剂蛋白-1(AP-1),它们构成各种类胡萝卜素与其它微量营养素协同抗癌作用的基础。

Carotenoida exhibit a well - known anticancer effect through interference in several pathways related to cancer cell growth and cell death, including cell proliferation, growth factor signaling, gap junctional intercellular communication,cell differentiation and apoptosis. Carotenoids cause changes in the expression of many regulatory proteins participaring in these processes. The role of several transcription systems has been found in the anticancer activity of carotenoids, such as the retinoid receptors, peroxisome proliferators - activated receptors （ PPAR）, the antioxidant response element （ARE） ,xenobiotic receptors and activator protein - 1 （AP - 1 ）. These transcription systems provide the molecular basis for the synergistic anticancer effects of the combinations of various carotenoids together with other micronutrients.