摘要
目的以肝星状细胞(HSC)为靶标探讨牛磺酸对门脉高压的影响。方法胶原晶格收缩法观察其对HSC-T6细胞收缩的影响,硝酸还原酶法测定一氧化氮(NO),化学比色法测定一氧化氮合酶(NOS)活性。结果牛磺酸能显著抑制HSC-T6收缩(P<0·05或P<0·01),抑制作用与剂量呈依赖关系;牛磺酸能增加HSC分泌NO和增强NOS的活性。结论牛磺酸具有一定的降低门脉高压的作用。
Objective To investigate the effect of taurine at hepatic stellate（HSC） on portal hypertension.Methods HSC-T6 cells contraction were studied by the contraction collagen lattice. The levels of NO, activity of nitric oxide synthase（NOS） were detected by nitric reductase and colorimetry. Results Taurlne can inhibit the contraction of HSC- T6 cells （P〈0.05 or P〈0.01）as direct relation of concentrations, taurine can inhibited the secretion of NO and accivity of iNOS.Conclusion Taurine can reduce portal hyension.
出处
《广西医学》
CAS
2006年第2期182-184,共3页
Guangxi Medical Journal
基金
广西壮族自治区自然科学基金资助项目(合同号:0144016)
