益气养阴祛瘀中药治疗干燥综合征的临床疗效及其对免疫功能的影响

Effects of Chinese Herbal Medicine for Yiqi Yangyin Quyu in Treating Sjgren’s Syndrome and on Patients' Immunologic Function

目的探讨益气养阴祛瘀中药对干燥综合征患者的免疫调节及治疗作用。方法62例干燥综合征患者随机分成治疗组(37例)和对照组(25例),治疗组给予益气养阴祛瘀中药和泼尼松治疗,对照组单独服用泼尼松治疗,治疗前和治疗3个月后分别观察临床疗效、检测免疫球蛋白(immunoglobulin,Ig)及T淋巴细胞亚群的变化,同时选健康人20名为正常组检测免疫球蛋白及T细胞亚群。结果治疗前免疫球蛋白(IgG、IgM、IgA)均高于正常组,NK细胞、CD4比例均低于正常组,治疗3个月后,两组患者IgG、IgM、IgA都下降至正常范围(P<0.05),NK细胞、CD4比例较治疗前有所回升(P<0.05),而CD3对照组低于治疗组(P<0.05)。临床疗效治疗组(91.9%)优于对照组(76.0%,χ2=3.92,P<0.05)。结论益气养阴祛瘀中药能够提高干燥综合征患者的临床疗效,同时能调节患者的免疫功能。

Objective To investigate the immuno-regulatory and therapeutic effects of Chinese herbal medicine for Yiqi Yangyin Quyu （YYQ, supplementing qi, nourishing yin, removing blood stasis） on Sj6gren＇s syndrome （SS）. Methods Sixty-two patients were randomly divided into the treated group（37 cases）treated with Chinese medicine and prednisone, and the control group （25 cases） treated with prednisone alone, and another 20 healthy persons were taken as the normal control group. Curative effects was observed, and immunoglobulin （Ig） and T lymphocyte subsets were detected before and after 3 months＇ treatment. Results Immunoglobulin （IgG, IgM and IgA） before treatment in SS patients were higher, while the proportion of natural killer （NK） cell and CD4 were lower as compared with those in the normal control group. After treatment, IgG, IgM and IgA lowered to normal levels （P〈0.05）, the proportion of NK cell and CD4 rose in both groups （P〈 0.05）, but CD3 in the control group was still lower than that in the treated group （P 〈 0.05）. The total curative effective rate in the treated group was 91.9%, better than that in the control group （76.0%, X^2= 3.92, P 〈 0.05）. Conclusion Chinese herbal medicine for YYQ could improve clinical curative effective rate and regulate immune function in SS patients.