摘要
目的:研究复方龙葵胶囊对2-乙酰基芴(2-AFF)诱导大鼠肝癌的影响。方法:肝癌模型以0.05%2-AFF的饲料喂养SD大鼠10周。给予不同剂量复方龙葵灌胃,观察大鼠一般情况,检测肝脏指数、ALT、AST、γ-GT及肝组织的病理学。结果:与模型组比较,龙葵各剂量组和阳性对照组肝脏指数均显著降低(P<0.01)。肝功能指标均显著低于模型组(P<0.01),各组之间差异无显著性。结论:复方龙葵胶囊对实验性大鼠肝癌有明显的抑制作用。
Objective:To observe the effect of the compound solanum nigrum on liver cancer induced by 2-acetamidofluorene (2- AFF) in rats. Methods: An aimal model of liver cancer was established by feeding SD rats with 0.05% 2-AFF, compound solanum nigrum of different doses were administrated orally,then indexes of Iiver, ALT,AST and γ-GT were detected and the patloologic changes were observed. Results: The liver indexes in the solanum nigrum administrated groups and the positive group decreased evidently(P〈 0.01) compared with those in the negative control group. The ALT,AST and γ-GT in all treatment groups were much lower than those in the control group (P〈0.01), and there was an significant difference between groups with treatment. Conclusion: The compound solarium nigrum capsuals have evident inhibitory action on experimental liver cancer induced by 2-AFF in rats.
出处
《中国交通医学杂志》
2006年第2期131-132,135,共3页
Chinese Medical JOurnal of Communications