血液透析患者冠状动脉钙化调查和分析

Survey and analysis of coronary artery calcification in maintenance hemodialysis patients

目的观察维持性透析患者与普通人群冠状动脉、降主动脉钙化情况,并了解透析患者冠状动脉钙化的因素。方法采用菲利浦螺旋CT扫描以钙化积分确定冠状动脉和降主动脉钙化的程度,比较透析患者和普通人群血管钙化情况,以冠状动脉钙化和非钙化对透析患者分组,比较两组临床资料。结果透析患者较普通人群有更严重的冠状动脉钙化和降主动脉钙化,透析患者冠状动脉钙化组与非钙化组存在apo-A、C反应蛋白、白蛋白、血磷、钙磷乘积、年龄、透析龄的差异,钙化积分与apo-A相关。结论维持性血液透析患者较普通人群更易发生冠状动脉钙化,透析患者冠状动脉钙化与年龄、透析龄、年龄、炎症、钙磷代谢等有关。

Objective To investigate the coronary artery and descending aorta calcification in maintenance hemodialysis patients and normal controls and to analyze the factors of coronary artery calcification in hemodialysis patients, Method All subjects underwent coronary artery and descending aorta CT scan using Philip＇ s spiral CT and the calcification degree were evaluated by calcification scores, The calcification status of hemodialysis patients and normal controls were compared and the hemodialysis patients were divided into coronary artery calcification group and noncoronary artery calcification group according to the CT scan result, Results There was more severe calcification of coronary artery and descending aorta in hemodialysis patients than that in normal controls. And there were significant differences in A,C reactive protein, albumin, phosphorus, calcium phosphorus product, age and hemodialysis vintage between coronary artery calcification group and noncoronary artery calcification group. Calcification scores was correlated with apo-A. Conclusion Maintenance hemodialysis patients have more probability to have coronary artery calcification than normal controls. The coronary artery calcification of hemodialysis patients had close correlation with age, duration of hemdialysis, infection and calcium phosphate metabolism.