氯铝酸离子液体中Glyoxylate-Ene反应合成α-羟基酯

Synthesis of α-Hydroxy Esters by Glyoxylate-Ene Reaction in Lewis Acid Chloroaluminate Ionic Liquids

The chloroaluminate ionic liquid,composed of AlCl3 and 1-butyl-3-methylimidazolium chloride（Cl）,is used as the solvent and catalyst to synthesize α-hydroxy esters from alkene and glyoxylate via the glyoxylateene reaction.Under the reaction conditions of 15 ℃,4 h,and AlCl3/Cl molar ratio of 2,the ethyl α-hydroxy-4-phenyl-4-pentenoate with high yield（95.2%） is obtained in the reaction of α-methyl styrene and ethyl glyoxylate.Other α-hydroxy esters can also be obtained in high yields through the glyoxylate-ene reaction.Moreover,the chloroaluminate ionic liquid can be reused several times.

The chloroaluminate ionic liquid, composed of AlCl3 and 1-butyl-3-methylimidazolium chloride （[bmim]Cl）, is used as the solvent and catalyst to synthesize α-hydroxy esters from alkene and glyoxylate via the glyoxylate-ene reaction. Under the reaction conditions of 15 ℃ , 4 h, and AlCl3/[ bmim] Cl molar ratio of 2, the ethyl a-hydroxy-4-phenyl-4-pentenoate with high yield （95.2%） is obtained in the reaction of α-methyl styrene and ethyl glyoxylate. Other α-hydroxy esters can also be obtained in high yields through the glyoxylateene reaction. Moreover, the chloroaluminate ionic liquid can be reused several times.